eng Science and Education Publishing International Journal of Dental Sciences and Research 2333-1259 2020-04-27 8 3 80 82 10.12691/ijdsr-8-3-5 IJDSR2020835 article Esra Duzyol 1 Sabiha Aydogdu 2 Mustafa Duzyol mustfadzyl@gmail.com 3 Nilgun Akgul 4 Istanbul Medeniyet University, Faculty of Dentistry, Department of Pediatric Dentistry, Istanbul, Turkey Ataturk University, Faculty of Medicine, Department of Microbiology, Erzurum, Turkey Istanbul Medeniyet University, Faculty of Dentistry, Department of Restorative Dentistry, Istanbul, Turkey Pamukkale University, Faculty of Dentistry, Department of Restorative Dentistry, Denizli, Turkey Objective: Antibacterial effect of several root canal sealers were compared which have different chemical structures. Materials And Methods: Enterococcus faecalis (EF) incubated into brain-heart infusion agar at 37 C for 24 h. 20 mg of used root canal sealers were impregnated blank antimicrobial discs which were Endomethasone N, AH Plus, MTA Fillapex and Sealapex. Each plates were separated four quadrants and root canal sealers impregnated antimicrobial discs were inserted into their quadrants. Inhibition zones were measured with eye-witness on the plates by well-educated specialist after 48 h. Results: Endomethasone N have made higher inhibiton zones than other root canal sealers. AH Plus has larger inhibition zone than MTA Fillapex and Sealapex. Sealapex has less antibacterial effect on E. Faecalis. Conclusion: The results demostrated that eugenol based root canal sealers have significant antibacterial effects. http://pubs.sciepub.com/ijdsr/8/3/5/ijdsr-8-3-5.pdf Antimicrobial effect root canal sealer E Faecalis eugonol MTA based resin sealer calcium hydroxide epoxide-amide resins