eng Science and Education Publishing International Journal of Dental Sciences and Research 2333-1259 2016-03-03 4 2 17 19 10.12691/ijdsr-4-2-1 IJDSR2016421 article Mehmet Selcuk Ozbek selcuk233@yahoo.com 1 Suleyman Kaman 2 Kemal Ozgur Demiralp 3 Department of Endodontics, Ministry of Health, Oral and Dental Health Hospital, Eski?ehir, Turkey Department of Oral and Maxillofacial Surgery, Ministry of Health, Oral and Dental Health Hospital, Eski?ehir, Turkey Ministry of Health, Public Hospitals Agency, Ankara, Turkey In endodontics, separated endodontic instruments located in the mandibular canal may cause an injury of the inferior alveolar nerve (IAN) resulting in disabling sensory disturbances such as pain, paraesthesia, and dysaesthesia of the lower lip and chin area. In clinically paraesthesia usually manifests as numbness, tingling or any deviation from normal sensation. The suggested therapeutic sequence for endodontic related paraesthesia is the control of pain and inflammation and, whenever possible, the surgical elimination of the cause. A healthy 33-year-old woman was referred to the Department of Endodontics, Oral and Dental Healthy Hospital, Eski?ehir suffering from pain and paraesthesia in the left lower lip and chin. Radiographic examination revealed the presence of a separated endodontic instrument beyond the apex of the mandibular left second molar and this instrument was inside the left mandibular canal. Damage to the IAN secondary to extrusion of a separated endodontic instrument was diagnosed. Extraction of the tooth was decided and after prednisone and pregabalin treatments both pain and paraesthesia on the left side of the lower lip and chin were gone. http://pubs.sciepub.com/ijdsr/4/2/1/ijdsr-4-2-1.pdf separated endodontic instrument inferior alveolar nerve pregabalin