Science and Education Publishing International Journal of Dental Sciences and Research 2 3 2014 05 11 Fibroblast Heterogeneity in Periodontium - a Review 50 54 EN Dr. A. Archana Dr. Venkata Srikanth Dr. Sasireka Dr. Bobby Kurien Department of Periodontics, Adhiparasakthi Dental College, Chennai, India Dr. Ebenezer IJDSR2014231 10.12691/ijdsr-2-3-1 2014 04 28 2014 05 09 2014 05 11 Fibroblast heterogeneity applies to both phenotypic and functional properties exhibited by a fibroblast population within or across tissues (Mc Culloch et al) There is significant evidence that fibroblasts are heterogeneous with respect to functional properties, and that certain subpopulations of these cells may be clonally selected and expanded in diseased tissues. There are wide variations of gene expression and strikingly different responses to extracellular signals among different fibroblast populations. This has prompted a large number of in vitro studies which suggest that fibroblasts are not homogeneous but instead comprise multiple subpopulations with extensive site-to-site and intra-site variations.