Science and Education Publishing International Journal of Dental Sciences and Research 2 1 2014 01 20 The Role of Antibiotics in Treatment of Chronic Periodontitis 16 18 EN Priyavadhana Prabhu Research Scholar in Medical Microbiology, Bharath University, Chennai, India M.N. Prabhu M. Elumalai IJDSR2014215 10.12691/ijdsr-2-1-5 2013 11 18 2014 01 09 2014 01 20 Systemic antibiotics may be a necessary adjunct in controlling bacterial infection because bacteria can invade periodontal tissues, making mechanical therapy alone sometimes ineffective. An ideal antibiotic for use in prevention and treatment of periodontal diseases should be specific for periodontal pathogens, allogenic and nontoxic, substantive, not in general use for treatment of other diseases, and inexpensive . Combination of antibiotics may be necessary to eliminate all putative pathogens from some periodontal pockets. The guidelines for use, structure and origin, mechanisms of action of antibiotics are discussed in this paper. Also the recommended antibiotic dosages in Periodontal therapy is reviewed in this paper.