@article{ijcn2014212,
author={{Hozayen, Walaa G. and Seif, Howida S. Abou and Amin, Susan},
title={Protective Effects of Ruitn and / or Hesperidin Against Doxorubicin-Induced Hepatotoxicity},
journal={International Journal of Clinical Nutrition},
volume={2},
number={1},
pages={11--17},
year={2014},
url={http://pubs.sciepub.com/ijcn/2/1/2},
abstract={The present study was conducted to evaluate the protective role of rutin and hesperidin on experimental doxorubicin induced hepatotoxicity. Doxorubicin (DXR) administered rats (25 mg / kg; three times intraperitoneally / week for two weeks) were pretreated with rutin, hesperidin, or their mixture (50 mg / kg body weight) three times per week for three weeks. Results showed that DXR caused a marked rise in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) activities alongside an increase in serum total bilirubin, ¦Á-fetoprotein (AFP) and sialic acid levels Concerning oxidative stress and antioxidant defense system, the depleted hepatic glutathione content of DXR-administered rats was increased above normal levels as a result of pretreatment with rutin, hesperidin and both rutin and hesperidin. However, while elevated lipid peroxidation was noticed in DXR treated rats, pretreatment with rutin, hesperidin or both produced a detectable decrease in the lipid peroxidation level. Taken these data together, it can be concluded that natural plant components such as Rutin and Hesperidin could protect the liver against DXR-induced liver toxicity.},
doi={10.12691/ijcn-2-1-2}
publisher={Science and Education Publishing}
}