Science and Education Publishing International Journal of Clinical and Experimental Neurology 5 1 2017 3 23 Hyper Homocysteinemia Related Cerebral Venous Sinus Thrombosis -Presenting as Generalised Tonic-Clonic Seizure -A Case Report 5 8 EN Soumyabrata Roy Chaudhuri Senior Registrar, KPC Medical College, 1F, Raja Subodh Chandra Mullick Road Jadavpur, Kolkata West Bengal, India Deep Das Subhayan Bhattacharya Subhankar Chakraborty Kingshuk Bhattacharjee IJCEN2017512 10.12691/ijcen-5-1-2 2016 10 12 2017 2 13 2017 3 21 Cerebral venous sinus thrombosis (CVST) is a neuromuscular disorder with protean manifestation requiring a high index of suspicion. Early diagnosis is sometimes lifesaving. It is particularly challenging is to establish an accurate etiology as it guides the clinician for long term thrombo-prophylaxis. We report a young female with no conventional risk factors for CVST, who presented with headache, generalised seizures and prolonged loss of consciousness. Her work-up revealed an elevated serum homocysteine level which might be a possible causative association in the etiopathogenesis of this neuromuscular condition.