@article{ijcen2015321,
author={{Kobayashi, Shigeru and Suzuki, Yoshihiko and Yamada, Syuichi and Al-Khudairi, Naji and Meir, Adam},
title={Cyclooxygenase Expression in Canines Following Peripheral Nerve Injury},
journal={International Journal of Clinical and Experimental Neurology},
volume={3},
number={2},
pages={26--31},
year={2015},
url={http://pubs.sciepub.com/ijcen/3/2/1},
abstract={In order to investigate the mechanism of neurogenic pain, this study used a median nerve compression model in dogs. The nerve was compressed with a clip for three weeks. Immunohistochemistry was done by the avidin-biotin-peroxidase complex method to observe the changes of T cells (CD45) and macrophages (Mac-1) after compression. Antibodies against cyclooxygenase (COX)-1 and 2 were used to examine the localization and changes of these mediators caused by nerve compression. In control animals, resident T cells were detected, but there were no macrophages. COX-2 was positive in the Schwann cells and vascular endothelial cells, while COX-1 was detected in the vascular endothelial cells. After nerve compression, numerous T cells and macrophages appeared among the demyelinized nerve fibers. The macrophages were positive for COX-2. COX-2 may be deeply involved in neuritis arising from mechanical compression, and this mediator seems to be important in the manifestation of neurogenic pain.},
doi={10.12691/ijcen-3-2-1}
publisher={Science and Education Publishing}
}