@article{ijcen2013112,
author={{Zhao, Yu and Wang, Shijun},
title={Neural Stem Cell Transplantation Inhibits Apoptosis through Activation of MAPK/ERK Signaling Pathway in Cerebral Ischemia/Reperfusion Rats},
journal={International Journal of Clinical and Experimental Neurology},
volume={1},
number={1},
pages={5--11},
year={2013},
url={http://pubs.sciepub.com/ijcen/1/1/2},
abstract={Apoptosis, a major pathogenesis of cerebral ischemia, is closely associated with the dysregulation of MAPK/ERK signaling pathway. The transplantation of neural stem cells (NSCs), as a therapeutic target of cerebral ischemia, could repair missing cells and the activation of endogenous cells to provide "self-repair". However, the neuroprotective mechanism of the transplantation of NSCs against cerebral ischemia injury is unclear. This study is to investigate the effect of the transplantation of NSCs on apoptosis and MAPK/ERK signaling in the cerebral ischemia/reperfusion rats to evaluate its neuroprotective role. These results suggest that the transplantation of NSCs provides a neuroprotective effect <i>via</i> decreasing neurological deficit and increasing the activity of MAPK/ERK signaling in MCAO-lesioned brains and restraining apoptosis. In view of the treatment and prevention of ischemic brain damage, the ability of NSCs to enhance the activity of MAPK/ERK signaling and inhibit apoptosis may be of great importance in the selection of neuroprotective agents.},
doi={10.12691/ijcen-1-1-2}
publisher={Science and Education Publishing}
}