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American Journal of Public Health Research
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The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
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The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
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Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
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The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

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Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies

Elena Cristina Garbovan, Cornel Aldea, Genel Sur, Ciprian Silaghi, Anamaria Garbovan*

Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Abstract: The association of celiac disease with chronic hepatitis C virus infection was intensely debated. We aimed to study the prevalence of celiac disease in patients with chronic hepatitis C virus infection.

Keywords: celiac disease, hepatitis C, prevalence

Received June 26, 2019; Revised August 04, 2019; Accepted August 13, 2019

Citation: Elena Cristina Garbovan, Cornel Aldea, Genel Sur, Ciprian Silaghi, Anamaria Garbovan, Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies. International Journal of Celiac Disease, 7 (2). 46-47. January 2019. doi:10.12691/ijcd-7-2-8

Association between celiac disease and chronic hepatitis C virus infection has been reported in many studies [1.2]. We want to see in this editorial the prevalence of celiac disease in patients with hepatitis C. Lindgren et al reported that celiac disease has a prevalence of 1.5% in patients with chronic liver disease, which is higher than in general, however this could be explained by the fact that celiac disease was often described as underdiagnosed [1]. A study on 259 patients revealed that there is a higher prevalence of anti-gliadin antibodies in patients with liver disease such as chronic hepatitis C virus, autoimmune liver disease, and other hepatic diseases than in controls [2]. Moreover, the correlation between celiac disease and chronic hepatitis C virus could consist in the silent activation of celiac disease during interferon treatment which is often unsuspected due to the fact that interferon can lead to the induction of pre-existent autoimmune disorders [3]. In literature have been reported several cases of celiac disease onset during interferon therapy [4-7]. However, Mbbs et al published a series of four cases of celiac disease onset in patients with chronic hepatitis C virus that did not undergo interferon and ribavirin therapy [8]. A study on 210 patients with chronic hepatitis C virus revealed that the prevalence of celiac disease among chronic hepatitis C virus patients is 0%, while the prevalence of chronic hepatitis C virus on 194 celiac disease patients is 1.54% comparable with the general population, furthermore there is a lack of correlations between PEG interferon-α and celiac disease [9]. Ruggeri et al concluded that the prevalence of anti-endomysial antibodies in chronic hepatitis C virus patients is independent with autoimmunity [10]. Another study on 120 patients with portal hypertension revealed the fact that celiac disease has a a higher prevalence in patients with cryptogenic chronic liver disease (10%) and idiopathic noncirrhotic intrahepatic portal hypertension (14%) than in hepatitis B/C-related cirrhosis (0%) [11]. Studying Table 1 we can conclude that in no study the prevalence of celiac disease in chronic hepatitis C virus patients is higher than the global prevalence of chronic hepatitis C virus (2.5%) [12]. The prevalence of celiac disease in chronic hepatitis C virus patients is summarized in Table 1. In conclusion, we can observe that the prevalence of celiac disease in chronic hepatitis C virus patients is decreasing over time.

Table 1. Prevalence of CD and auto-antibodies in HCV patients

Conflict of Interest

All authors contributed equally to this work.

All authors of this paper have read and approved the final version submitted.

The authors have declared that no conflict of interest exists.

Acknowledgements

`Anamaria Garbovan received a grant from the University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj–Napoca 2016, project no. 4995/21/08.03.2016.

References

[1]   | Samaşca G, Burac L, Farcău D, Dejica D. Screening for celiac disease in chronic viral hepatitis C. Romanian Journal of Pediatrics 2010; 59(1): 49-50.
[2]   | Aldea C, Sur D, Silaghi C. Hypercoagulability State in Celiac Disease and Hepatitis C Association. International Journal of Celiac Disease 2018; 6 (3): 74-751.
[3]   | Lindgren S, Sjoberg K, Eriksson S. Unsuspected coeliac disease in chronic “cryptogenic” liver disease. Scand J Gastroenterol. 1994; 29(7): 66-4.
[4]   | Fine KD, Ogunji F, Saloum Y, Beharry S, Crippin J, Weinstein J. Celiac sprue: another autoimmune syndrome associated with hepatitis C. Am J Gastroenterol. 2001; 96(1): 138-45.
[5]   | Durante-Mangoni E, Iardino P, Resse M, Cesaro G, Sica A, Farzati B, et al. Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome. J Clin Gastroenterol. 2004; 38(10): 901-5.
[6]   | Ionita-Radu F, Bucurica S, Costache R, Nuta P, Stanciu S. An adult case with onset of celiac disease during chronic hepatitis C antiviral treatment. Rom J Intern Med. 2010; 48(1): 105-8.
[7]   | Gombosova L, Jarcuska P, Benova B, Benicky M, Lazurova I. Celiac disease manifested during the treatment of chronic hepatitis C by pegylated alpha interferon and ribavirin. Bratisl Lek Listy. 2011; 112(6): 360-2.
[8]   | Singh A, Zaeri N, Ho IK. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy. Case Reports in Hepatology 2015; 2015: 10-3.
[9]   | Vasudevan A, Lubel JS. Case report New-onset of celiac disease during interferon-based therapy for hepatitis C. Gastroenterol Rep (Oxf). 2015; 3(1): 83-5.
[10]   | Mbbs AG, Dm CR, Duseja A, Facg DM, Chawla Y, Fams DM. Association between Celiac Disease and Chronic Hepatitis C. J Clin Exp Hepatol 2011; 1(1): 41-4.
[11]   | Gravina AG, Federico A, Masarone M, Cuomo A, Tuccillo C, Loguercio C, et al. Coeliac disease and C virus-related chronic hepatitis: a non association. BMC Res Notes. 2012; 5: 533.
[12]   | Ruggeri C, La Masa AT, Rudi S, Squadrito G, Di Pasquale G, Maimone S, et al. Celiac disease and non-organ-specific autoantibodies in patients with chronic hepatitis C virus infection. Dig Dis Sci. 2008; 53(8): 2151-5.
[13]   | Maiwall R, Goel A, Pulimood AB, Babji S, Sophia J, Prasad C, Balasubramanian KA, Ramakrishna B, Kurian S, Fletcher GJ, Abraham P, Kang G, Ramakrishna BS, Elias E, Eapen CE.Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014; 33(6): 517-23.
[14]   | Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016; 22(34): 7824-40.
[15]   | Villalta D, Girolami D, Bidoli E, Bizzaro N, Tampoia M, Liguori M, et al. High Prevalence of Celiac Disease in Autoimmune Hepatitis Detected by Anti-Tissue Tranglutaminase Autoantibodies. J Clin Lab Anal. 2005; 10(2004): 6-10.
[16]   | Thevenot T, Denis J, Jouannaud V, Monnet E, Renou C, Labadie H, et al. Coeliac disease in chronic hepatitis C: a French multicentre prospective study. Aliment Pharmacol Ther. 2007; 26(9): 1209-16.
[17]   | Hernandez L, Johnson TC, Naiyer AJ, Kryszak D, Ciaccio EJ, Min A, et al. Chronic hepatitis C virus and celiac disease, is there an association? Dig Dis Sci. 2008; 53(1): 256-61.
[18]   | Sarmiento L, Galvan A, Cabrera-rode E, Aira L, Sarmiento L, Correa C, Sariego S, et al. Type 1 Diabetes Associated and Tissue Transglutaminase Autoantibodies in Patients Without Type 1 Diabetes and Coeliac Disease With Confirmed Viral Infections. J Med Virol. 2012; 84(7): 1049-53.
[19]   | Gravina AG, Federico A, Masarone M, Cuomo A, Tuccillo C, Loguercio C, et al. Coeliac disease and C virus-related chronic hepatitis: a non association. BMC Res Notes. 2012; 5: 533.
[20]   | Marconcini ML, Fayad L, Shiozawa MBC, Dantas-Correa EB, Lucca Schiavon L de, Narciso-Schiavon JL. Autoantibody profile in individuals with chronic hepatitis C. Rev Soc Bras Med Trop. 2013; 46(2): 147-53.