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Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
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Celiac Disease & Lymphoproliferative Malignancy at Adulthood

Hakim Rahmoune*, Nada Boutrid, Mounira Amrane, Soraya Ouhida, Djamel Abdellouche, Belkacem Bioud

Department of Pediatrics, University Hospital of Setif, Setif 1 University, Algeria

Abstract: Celiac disease (CD) is associated with an increased risk for malignancy, specially lymphoproliferative. During a retrospective annual study of intestinal biopsies results in the pathology department at the University Hospital of Setif, we were only half surprised to find a lymphoma in an adult patient initially presenting a CD. We briefly present this case with a review of the current literature.

Keywords: celiac disease, lymphoproliferative malignancy, gastrointestinal cancers

Citation: Hakim Rahmoune, Nada Boutrid, Mounira Amrane, Soraya Ouhida, Djamel Abdellouche, Belkacem Bioud, Celiac Disease & Lymphoproliferative Malignancy at Adulthood. International Journal of Celiac Disease, 6 (2). 47-48. January 2018. doi:10.12691/ijcd-6-2-7

1. Introduction

Celiac disease (CD) is an auto-immune disease triggered by dietary exposure to gluten in genetically susceptible population (carrying HLA-DQ2 Or HLA-DQ8) [1].

CD in adulthood depicts a higher frequency extra_intestinal manifestations as well as many associations with other immune mediated diseases and malignanciers. Particularly, CD is associated with an increased risk for lymphoproliferative malignancy, while other types of malignancies are sparsely reported [2,3].

2. Material and Method

We made a retrospective study of the reports of intestinal biopsies in celiac patients in the University Hospital of Setif.

Thus, a group of interns in medicine collected the histological reports of these biopsies at the department of pathology during the year 2016 (from January 1st to December 31st, 2016).

We analyzed various data including the different associated lesions in celiac population.

3. Results

We collected fifty nine (59) reports of both adult and pediatric celiac patients (32 adults and 17 children).

We found one patient (1.7% of the total reports) that associated celiac disease and intestinal (small bowel) lymphoma.

Further information about this case (a female patient, 41 years old) could not been obtained (anonymous data).

4. Discussion

Evidence, including population-based studies, confirmed that patients with diagnosed CD are at increased risk of malignancy and mortality [4,5].

Notably, patients with CD have an increased risk of lympho-proliferative malignancy and gastrointestinal cancer; and enteropathy-associated T cell lymphoma may occur in a subgroup of patients with refractory CD [6,7].

Inversely, reduced IgA and IgG levels lead to a lower detection rate of serological screening for CD in patients with a history of lymphoma [8].

A recent meta-analysis found that CD was particularly associated with an overall increased risk of gastro-intestinal malignancies like esophageal cancer and small intestinal carcinoma [9].

Persistent villous atrophy during CD compared with mucosal healing was associated with an increased risk for lymphoproliferative neoplasms [10].

In such cases of complicated CD, enteroscopy (wireless or wired) is considered as an efficient diagnostic tool for the detection of malignant and premalignant lesions of the small bowel [11,12].

At the opposite, some evidence suggests that a gluten free diet could reduce the risk of lymphoproliferative malignancy, and even reduces the overall risk of mortality [4].

As mentioned before, in addition to digestive neoplasms, CD patients present also a higher risk to develop other malignancies like [13,14,15].

5. Conclusion

Celiac disease prevalence is increasing worldwide, and awareness about its complications should also increase.

Malignancies are a well-recognized risk in celiac adults ; and this potential risk is affected by precocious diagnosis and correct management (including the cornerstone gluten free diet).

Counseling and recognizing such at-risk patients would be a valuable, highly effective predictive medicine.

Acknowledgments

We would warmly thank the interns that collected the data for this work, Doctors: Mouaad Boucherit, Kenza Bouchikh, Kamel Boudjerada, Hanane Boulahlib, Manal Boulmerka, Lamri Djehida, Youcef Jabari and Hichem Khelifi.

References

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[3]   | Freeman HJ. Celiac disease and selected long-term health issues. Maturitas. 2012 Nov 1; 73(3): 206-11.
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[5]   | Rubio-Tapia A, Ludvigsson JF, Brantner TL, Rajkumar SV, Landgren O, Murray JA. Increased mortality among men aged 50 years old or above with elevated IgA anti-transglutaminase antibodies: NHANES III. BMC gastroenterology. 2016 Dec; 16(1): 136.
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[7]   | Elfström P, Granath F, Ekström Smedby K, Montgomery SM, Askling J, Ekbom A, Ludvigsson JF. Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. Journal of the National Cancer Institute. 2011 Feb 2; 103(5): 436-44.
[8]   | Balihar K, Kozeluhova J, Hejda V, Krcma M, Lysak D, Gorcikova J, Hes O, Matejovic M. Diagnosing celiac disease in patients with a history of lymphoma: factors that matter. Wiener klinische Wochenschrift. 2013 Nov 1; 125(21-22): 696-703.
[9]   | Han Y, Chen W, Li P, Ye J. Association between coeliac disease and risk of any malignancy and gastrointestinal malignancy: a meta-analysis. Medicine. 2015 Sep; 94(38).
[10]   | Lebwohl B, Granath F, Ekbom A, Smedby KE, Murray JA, Neugut AI, Green PH, Ludvigsson JF. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study. Annals of internal medicine. 2013 Aug 6; 159(3): 169-75.
[11]   | Tomba C, Elli L, Bardella MT, Soncini M, Contiero P, Roncoroni L, Locatelli M, Conte D. Enteroscopy for the early detection of small bowel tumours in at-risk celiac patients. Digestive and Liver Disease. 2014 May 1; 46(5): 400-4.
[12]   | Elli L, Casazza G, Locatelli M, Branchi F, Ferretti F, Conte D, Fraquelli M. Use of enteroscopy for the detection of malignant and premalignant lesions of the small bowel in complicated celiac disease: a meta-analysis. Gastrointestinal endoscopy. 2017 Aug 1; 86(2): 264-73.
[13]   | Green PHR, Aaron TF, Bhagat G, et al. Risk of malignancy in patients with celiacdisease. American Journal of Medicine 2003: 115.
[14]   | Grainge MJ, West J, Solaymani-Dodaran M, et al. The long-term risk ofmalignancy following a diagnosis of coeliac disease or dermatitis herpeti-formis: a cohort study. Alimentary Pharmacology and Therapeutics 2012; 35: 730–9.
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[16]   | Ilus T, Kaukinen K, Virta LJ, et al. Incidence.