eng Science and Education Publishing International Journal of Celiac Disease 2334-3486 2017-03-02 5 1 24 27 10.12691/ijcd-5-1-5 IJCD2017515 article Aaron Lerner aaronlerner1948@gmail.com 1 2 Torsten Matthias 2 B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel Genetic and environmental risk factors for celiac disease are well established, however, the precipitating events leading to development of celiac disease and associated conditions remain enigmatic. Being a multi-faced, multi-organ disease and the multiple extra intestinal phenotypes of celiac disease, further more add to its complexity. The present editorial summarizes the potential mechanisms connecting gut eco system events to remote organ manifestations and dysfunctions in celiac disease. It is suggested that nutrients, the microbiome/dysbiome interplay, the local post translational modification of naive proteins, the leaky gut and the leaked immunogenic or toxic molecules or complexes and the circulating pro-inflammatory immune cells and cytokines are at the basis of the gut-remote organ pathologies, in CD. http://pubs.sciepub.com/ijcd/5/1/5/ijcd-5-1-5.pdf celiac diseases potential mechanisms gut eco system