Science and Education Publishing International Journal of Celiac Disease 2334-3486 4 2 2016 5 28 Nonspecific Symptoms in Celiac Disease- Case Report 71 73 EN Valentina Sas Camelia I. Bud Third Pediatric Clinic, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania Ioana Fodor Sorin C. Man IJCD2016429 10.12691/ijcd-4-2-9 2016 1 20 2016 3 21 2016 5 26 Celiac disease is an immune-mediated systemic disorder with a genetic predisposition. The availability of more specific serology tests showed that celiac disease is more common than previously suspected and that many patients do not demonstrate specific clinical or even histological sings. We present a case of celiac disease with the unset at 5 years, with recurrent episodes of diarrhea, weight loss and anemia. The serology tests showed a high level of IgA tissue transglutaminase antibodies, exceeding 10 times the upper limit but the intestinal biopsy showed normal size villi, intact surface epithelium and a lymphoplasmacytic infiltrate at chorionic level (Marsh 1). The diagnosis of celiac disease was confirmed by resolution of symptoms and normal tissue transglutaminase antibodies level, six month after starting the gluten free diet.