eng Science and Education Publishing International Journal of Celiac Disease 2334-3486 2016-05-28 4 2 68 70 10.12691/ijcd-4-2-1 IJCD2016421 article Aaron Lerner aaronlerner1948@gmail.com 1 Sandra Neidhöfer 2 Torsten Matthias 2 B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel AESKU.KIPP Institute, Wendelsheim, Germany An adult patient with IgA deficiency, celiac and Crohn's disease is described. In addition to the rare association, he developed an unusual proximal Crohn's disease. Unbalanced microbiome, increased intestinal permeability, susceptibility to infections that might initiate post translational modification of naïve protein and the genetic background, are shared between the three entities. It is speculated that the IgA immune deficiency and its consequences are the early factors that set the stage for the progression of the other two diseases. Based on recent knowledge, special nutritional therapies should be considered, in addition to the gluten free diet. http://pubs.sciepub.com/ijcd/4/2/1/ijcd-4-2-1.pdf celiac disease Crohn's disease IgA deficiency association small bowel case report