Science and Education Publishing International Journal of Celiac Disease 2334-3486 4 1 2016 2 18 Is HLA Typing a Diagnostic Tool in Celiac Disease? 9 10 EN Andreea L. Rachisan Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Alexandru Pirvan Nicolae Miu Dan Gheban Adrian Hrusca Gabriel Samasca Iulia Lupan IJCD20164110 10.12691/ijcd-4-1-10 2015 10 14 2015 12 15 2016 2 16 The 'four out of five rule' has not been officially endorsed by official guidelines. However, HLA-associated genes that predispose to CD are found in as much as 30-40% of healthy people. Thus, their presence seems too indecisive for the occurrence of CD.