eng Science and Education Publishing International Journal of Celiac Disease 2334-3486 2016-02-18 4 1 9 10 10.12691/ijcd-4-1-10 IJCD20164110 article Andreea L. Rachisan andreea_rachisan@yahoo.com 1 Alexandru Pirvan 1 Nicolae Miu 1 Dan Gheban 2 Adrian Hrusca 3 Gabriel Samasca 4 Iulia Lupan 5 Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Department of Biophysics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Department of Molecular Biology, Babes-Bolyai University, Cluj-Napoca, Romania The 'four out of five rule' has not been officially endorsed by official guidelines. However, HLA-associated genes that predispose to CD are found in as much as 30-40% of healthy people. Thus, their presence seems too indecisive for the occurrence of CD. http://pubs.sciepub.com/ijcd/4/1/10/ijcd-4-1-10.pdf celiac disease HLA children