Science and Education Publishing International Journal of Celiac Disease 2334-3486 3 2 2015 05 04 Neuropsychiatric Manifestations of Celiac Disease in Young Child - Case Report 69 71 EN Mircea Margescu II- nd Pediatric Department of Clinical Pediatrics Emergency Hospital Cluj-Napoca, Romania Camelia Carmen Margescu Rodica Elena Pantis MadalinaIonela Chiriac Rodica Cornean IJCD2015324 10.12691/ijcd-3-2-4 2015 04 06 2015 04 29 2015 05 04 Neurological and psychiatric symptoms represent an atypical manifestation of celiac disease (CD) occurring before the typical gastrointestinal events (weight loss, diarrhea, steatorrhoeic stools). Some studies suggest that a gluten-free diet is effective in treating psychiatric and neurological complications associated with CD. We report the case of 1 year and 10 months female child presented in II-nd Pediatrics Clinic of Clinical Pediatrics Emergency Hospital Cluj-Napoca with important neuropsychiatric manifestations (psychomotor tension, sobbing spasms, affective lability, separation anxiety and social anxiety, non-organic disorders sleeping) and typical manifestations of CD (loss of appetite, weight loss). The family history (paternal grandfather diagnose with intestinal lymphoma, mother suffering of type I diabetes and autoimmune thyroiditis - AT) relive the association with other autoimmune diseases and possible complications of CD. Complete remission of all clinical manifestations under the gluten confirms that symptoms were in the context of CD.