eng Science and Education Publishing International Journal of Celiac Disease 2334-3486 2015-05-04 3 2 69 71 10.12691/ijcd-3-2-4 IJCD2015324 article Mircea Margescu mirceammv@yahoo.com 1 2 Camelia Carmen Margescu 2 Rodica Elena Pantis 3 MadalinaIonela Chiriac 4 Rodica Cornean 4 4 II- nd Pediatric Department of Clinical Pediatrics Emergency Hospital Cluj-Napoca, Romania Pediatric Psychiatry Department of Clinical Pediatrics Emergency Hospital Cluj-Napoca, Romania Pediatric Surgery Department of Clinical Pediatrics Emergency Hospital Cluj-Napoca, Romania Neurological and psychiatric symptoms represent an atypical manifestation of celiac disease (CD) occurring before the typical gastrointestinal events (weight loss, diarrhea, steatorrhoeic stools). Some studies suggest that a gluten-free diet is effective in treating psychiatric and neurological complications associated with CD. We report the case of 1 year and 10 months female child presented in II-nd Pediatrics Clinic of Clinical Pediatrics Emergency Hospital Cluj-Napoca with important neuropsychiatric manifestations (psychomotor tension, sobbing spasms, affective lability, separation anxiety and social anxiety, non-organic disorders sleeping) and typical manifestations of CD (loss of appetite, weight loss). The family history (paternal grandfather diagnose with intestinal lymphoma, mother suffering of type I diabetes and autoimmune thyroiditis - AT) relive the association with other autoimmune diseases and possible complications of CD. Complete remission of all clinical manifestations under the gluten confirms that symptoms were in the context of CD. http://pubs.sciepub.com/ijcd/3/2/4/ijcd-3-2-4.pdf neuro-psychiatric manifestations child celiac disease autoimmunity