Science and Education Publishing International Journal of Celiac Disease 2328-3955 2 3 2014 09 17 Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors 93 96 EN Pavel Procházka Department of the Molecular Biology of Cancer, Institute of Experimental Medicine AS CR, Prague, Czech Republic IJCD2014236 10.12691/ijcd-2-3-6 2014 07 31 2014 09 10 2014 09 17 Celiac disease stands out as a major health problem with a frequent association with many other disorders. Studies show an increased risk of developing pancreatitis and after that pancreatic cancer in patients with celiac disease. A frequent occurrence and a remarkably close association with the HLA-DQ2 and/or DQ8 gene loci represent main genetic characteristic of celiac disease. A particular association was found with chromosome 15q26 and 6q21-22. On the other hand pancreatic tumors are known for associations with CTNNB1, VHL, CDKN2A, KRAS, TP53, RNF43, SMAD4, GNAS, PRSS1, ATM, BRCA1, BRCA2, PALB2, STK11 and hereditary non-polyposis colorectal cancer syndrome genes. Recent genetic mapping suggests that a large field of opportunities exists for better understanding of both diseases.