eng Science and Education Publishing International Journal of Celiac Disease 2328-3955 2014-09-17 2 3 93 96 10.12691/ijcd-2-3-6 IJCD2014236 article Pavel Procházka proch.pavel@gmail.com 1 Department of the Molecular Biology of Cancer, Institute of Experimental Medicine AS CR, Prague, Czech Republic Celiac disease stands out as a major health problem with a frequent association with many other disorders. Studies show an increased risk of developing pancreatitis and after that pancreatic cancer in patients with celiac disease. A frequent occurrence and a remarkably close association with the HLA-DQ2 and/or DQ8 gene loci represent main genetic characteristic of celiac disease. A particular association was found with chromosome 15q26 and 6q21-22. On the other hand pancreatic tumors are known for associations with CTNNB1, VHL, CDKN2A, KRAS, TP53, RNF43, SMAD4, GNAS, PRSS1, ATM, BRCA1, BRCA2, PALB2, STK11 and hereditary non-polyposis colorectal cancer syndrome genes. Recent genetic mapping suggests that a large field of opportunities exists for better understanding of both diseases. http://pubs.sciepub.com/ijcd/2/3/6/ijcd-2-3-6.pdf celiac disease pancreatic tumors HLA-DQ2 gene locus DQ8 gene locus KRAS BRCA1/2