@article{ijcd2014236,
author={Proch¨¢zka, Pavel},
title={Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors},
journal={International Journal of Celiac Disease},
volume={2},
number={3},
pages={93--96},
year={2014},
url={http://pubs.sciepub.com/ijcd/2/3/6},
issn={2328-3955},
abstract={Celiac disease stands out as a major health problem with a frequent association with many other disorders. Studies show an increased risk of developing pancreatitis and after that pancreatic cancer in patients with celiac disease. A frequent occurrence and a remarkably close association with the HLA-DQ2 and/or DQ8 gene loci represent main genetic characteristic of celiac disease. A particular association was found with chromosome 15q26 and 6q21-22. On the other hand pancreatic tumors are known for associations with <i>CTNNB1</i>,<i> VHL</i>,<i> CDKN2A</i>, <i>KRAS</i>, <i>TP53</i>, <i>RNF43</i>, <i>SMAD4,</i><i> </i><i>GNAS</i>, <i>PRSS1, ATM, BRCA1,</i><i> </i><i>BRCA2, PALB</i><i>2</i><i>,</i><i> </i><i>STK11</i><i> </i>and hereditary non-polyposis colorectal cancer syndrome genes. Recent genetic mapping suggests that a large field of opportunities exists for better understanding of both diseases.},
doi={10.12691/ijcd-2-3-6}
publisher={Science and Education Publishing}
}