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Greetings! I hope you are well.

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Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

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Science and Education Publishing (http://www.sciepub.com)

Celiac Disease: Far from Promised Land

Rocío Aguado, Orlando Estevez, Silvia Fernández, Consuelo Ortega, Manuel Santamaría*

Clinical Immunology Service, Reina Sofía University Hospital, Córdoba, Spain

Abstract:

Keywords:

Received February 01, 2014; Revised February 03, 2014; Accepted February 06, 2014

Citation: Rocío Aguado, Orlando Estevez, Silvia Fernández, Consuelo Ortega, Manuel Santamaría, Celiac Disease: Far from Promised Land. International Journal of Celiac Disease, 2 (1). 17-17. January 2014. doi:10.12691/ijcd-2-1-5

The diagnostic resources currently available in the first world countries have greatly improved with serological test, mainly anti-endomysium and anti-tissuetransglutaminase 2 autoantibodies detection. Nevertheless, identification of non-typical patients in serological terms remains as one of the main task to be afforded. In this sense, new biomarkers are currently emerging and should receive close attention. Among others has recently been observed that the regenerating gene I alpha protein, involved in tissue regeneration, is elevated in the sera of celiac patients and in their targeted tissue during tissue inflammation and damage, decreasing after gluten-free diet. Other significant example of a potential new biomarker in celiac disease consist of the intestinal fatty acid binding protein (I-FABP), whose levels are elevated in the celiac disease. Serum levels of I-FABP seems to correlate with the severity of enterocyte damage. Also a bunch of autoantibodies are arising over the skyline of celiac disease diagnose. Thus, IgA isotype anti-actin antibodies (IgA-AAA) presence, are somehow related to intestinal villous atropy in celiac disorder. Indeed, severe intestinal damage is observed in patients where IgA-AAA autoantibodies. Recently, ESPAGHAN included in its guidelines the detection of anti-deamidated gliadin peptide (DPG) antibodies that has been shown to be very efficient in the identification of the disease in children younger than 2 years-old. Failure to thrive usually prompts initial studies for celiac disease. In the absence of celiac disease markers, the differential diagnose with other causes leading to thriving failure is not always an easy task. Hence the interest of recently described autoantibodies such as anti-pituitary autoantibodies that can be detected in celiac disease patients with low plasmatic levels of insulin-like growth factor 1(IGF-1). And, of course, antibodies against other tissue transglutaminase family members (i.e. anti-TG3 and anti-TG6) found in celiac disease or CD associated conditions such as gluten ataxia. These are only some examples to illustrate the point of advances and future expectations in the sphere of celiac disease diagnose.

However, despite these and other exciting findings that will help, no doubts, to earlier and faster diagnoses of the disease in any circumstances, we are far away from the real understanding of the mechanisms underlying the disease and hence, from understanding factual therapies for it. Some old and apparently simple questions are yet awaiting to be solved out, such as the cofactor(s) enabling the disease to progress, or the cofactor braking it, in HLA-DQ2/8 individuals; the inability of the immune system to keep an homeostatic equilibrium in the gut of our patients remains deeply unknown; other points such as whether or not the disguised immune response triggered upon gluten ingestion in the susceptible individuals, is the cause or the consequence of the disease remains unanswered and requires a huge and internationally coordinated effort in basic research. Indeed, our progress in the ability to recognize the disease has stride but has not been accompanied by equivalent advances in the phisyopathogeneic knowledge nor in the therapeutical territories. Therefore, I will bet my money for basic research in celiac disease in the years to come, which would be definitely a priority, and the responsibility of the concerned scientific community in advances countries. This should be the way to change the famous definition of celiac disease as “tricky to find, hard to treat and impossible to cure” [1] by a new one, “easy to find, easy to treat and possible to cure” and then, if we manage to get it, I wish you were there.

References

[1]   | Lohiniemi, S., “Coeliac disease. Tricky to find, hard to treat, impossible to cure,” Lancet, 358(suppl.), S14, Dec 2001.