eng Science and Education Publishing International Journal of Celiac Disease 2334-3486 2023-09-04 11 1 32 35 10.12691/ijcd-11-1-7 IJCD20231117 article Hugh James Freeman hugfree@shaw.ca 1 James Gray 1 Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada Recently, a male patient, presented to multiple medical specialties that eventually led to development of diarrhea and weight loss followed by eventual review by a gastroenterologist and a specific diagnosis of Whipple¡¯s disease, a systemic disorder first described more than a century ago, but only recently recognized to be caused by Tropheryma whipplei. In this report, an updated review of this apparently very rare clinical disorder was done, including studies permitting a specific diagnosis of this disorder along with exclusion of other intestinal mucosal disorders that may potentially mimic Whipple¡¯s disease. http://pubs.sciepub.com/ijcd/11/1/7/ijcd-11-1-7.pdf Whipple¡¯s disease Tropheryma whipplei periodic acid Schiff positive macrophages Mycobacterium avium-intracellulare small intestinal malabsorption