eng Science and Education Publishing American Journal of Educational Research 2327-6150 2020-05-28 8 5 340 346 10.12691/education-8-5-18 EDUCATION20208518 article Luu Thi Hue 1 Vu Thi Tuyet 2 Tran Trung Ninh ninhtt@hnue.edu.vn 3 Son Tay High School, Hanoi, Vietnam Thanh Liem C High School, Ha Nam province, Vietnam Chemistry Faculty - Hanoi National University of Education, Vietnam STEM education is becoming a trend in many countries, including Vietnam. In the general education program, reduce the content of academic theoretical knowledge, instead of knowledge associated with reality and life, while emphasizing STEM education to meet the requirements of the 4.0 technology revolution. The article presents an overview of STEM; STEM-oriented teaching; Research the status and solutions for STEM activities in high school of Vietnam. From there, design the topic of Producing vinegar from sugar and fruit in teaching Carbohydrate chapter-Chemistry 12 under STEM orientation, to develop the ability to apply knowledge and skills to students. http://pubs.sciepub.com/education/8/5/18/education-8-5-18.pdf STEM education organic chemistry 12 Vinegar eating ability to apply knowledge and skills