eng Science and Education Publishing American Journal of Educational Research 2327-6150 2018-04-10 6 5 377 382 10.12691/education-6-5-2 EDUCATION2018652 article Nguyen Thi Kim Anh nguyenthikimanh@qnu.edu.vn 1 Tran Anh Tuan 2 Faculty of Chemistry, Quy Nhon University, Quy Nhon, Vietnam Quang Ngai Colleges, Quang Ngai, Vietnam The competence of knowledge manipulation to the life realities is a core competence needed to be established and developed for pupils in Chemistry. Various measures can be used in order to develop the competence of knowledge manipulation for pupils. This article offers the theoretical basis and four measures about the use of chemical knowledge through exercises in the classroom. Used in teaching as used when assigning homework to prepare new lessons; studying new texts; practicing and revision; experiments, practices to develop the competence of knowledge manipulation in many life realities such as health, medicine, environment, agriculture, food, industry,... for high school pupils of 12th grade through the system of metal chemistry exercises. http://pubs.sciepub.com/education/6/5/2/education-6-5-2.pdf competence of knowledge manipulation develop the competence of knowledge manipulation exercises of practical exercises exercises of competence development