eng Science and Education Publishing American Journal of Educational Research 2327-6150 2016-07-12 4 10 752 759 10.12691/education-4-10-8 EDUCATION20164108 article Orna Zeira ornaze@gmail.com 1 Department of Sciences, Academic College of Education Givat Washington, Bet Raban, Israel Today's education system operates in a dynamic, rapidly changing world. Our information era is characterized by an overload of information and countless technological developments. The digital online world has triggered a dramatic change in the hierarchical structure of information sources and access to information, which affect the learner, the teacher, the curriculum, the teaching-learning processes, and the learning environment. This paper suggests a teaching method that integrates computers to operate a lab called 'The Immune System - Models and Simulation' as a complementary method to teaching the immune system subject as part of biology lessons in high school. The results indicate significant improvement of students' content achievements and analysis abilities. Intelligent integration of computers in teaching, and its extension from a system that transfers information to a higher level of knowledge building and analysis could significantly improve students' achievements in science studies. http://pubs.sciepub.com/education/4/10/8/education-4-10-8.pdf meaningful learning digital learning science education constructive approach computerized models computerized simulation immune system