Science and Education Publishing American Journal of Educational Research 2333-4770 2 4 2014 03 19 Students Enrolled in Biology Majors Pre-Requisite Courses: Effect of High School Academic Performance 183 188 EN Mamta Singh Martin University, Indianapolis, Indianapolis Sandra West EDUCATION2014241 10.12691/education-2-4-1 2014 02 27 2014 03 15 2014 03 19 The purpose of this study was to enhance the ability of an institution to provide biology major students the best opportunity to succeed. Grades are universally measured variables. Regardless of different instructors teaching the same course in different sections, the final course grade is combined for all the sections representing one course. This study reflects the differences in students as they were successful in courses due to performance verse students who were not successful because of their low performance. The study used logistic regression analysis to assess students' performance in biology major courses. The findings suggest that high school GPA and high school chemistry were the predictors of students' success in entry-level biology courses.