eng Science and Education Publishing American Journal of Educational Research 2327-6150 2023-03-03 11 3 91 96 10.12691/education-11-3-1 EDUCATION20231131 article Didactic Sequence for Learning the Formulation of Medicines with the Use of ICT, at Upper Middle Level Heidi Cleofas Gardu?o 1 Miriam Aide Castillo Rodr¨ªguez aidmairim@comunidad.unam.mx 1 Obaya-Valdivia Adolfo Eduardo 1 Universidad Nacional Aut¨®noma de M¨¦xico, Facultad de Estudios Superiores Cuautitl¨¢n, Departamento de Ciencias Qu¨ªmicas, MADEMS (Qu¨ªmica) Av. Primero de Mayo s/n Cuautitl¨¢n Izcalli, Estado de M¨¦xico, M¨¦xico C.P 54740 The teaching of Chemistry has long been stigmatized as something difficult for teachers to do and at the same time complicated for students to understand. Some reasons may be the abstract nature of certain topics, among which is the identification of functional groups in compounds of biological interest such as the active principles of medicines. This article presents the structuring and implementation of a didactic strategy focused on the teaching-learning process of the subject of Chemistry for the theme Formulation of Medicines for which it was supported using ICT (Information and Communication Technologies). Subject taught in the curriculum of the College of Sciences and Humanities belonging to the National Autonomous University of Mexico at the high school level. The development of the strategy is based on an instructional design type ADDIE (Analysis, Design, Development, Implementation., Evaluation) which allows to have the opportunity for a continuous improvement of the strategy, using LKT (Learning and Knowledge Technologies) tools with a playful approach. The subject of the formulation of medicines is novel for students due to the social and environmental impact it can have on everyday life, in addition, the use of analogies allows a transfer of the knowledge taught to something more common and close to students. The results obtained reflected the influence that the use of LKT with a playful approach can have on student learning on the topic of drug formulation measured through the calculation of Hake's learning gain. We can take as an indication that the improvement of learning is real by using playful activities in the teaching of topics such as the identification of functional groups in medicines. http://pubs.sciepub.com/education/11/3/1/education-11-3-1.pdf Formulation medicines instructional design ICT LKT upper middle didactic sequence teaching-learning