eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2020-06-21 8 2 21 25 10.12691/ajps-8-2-1 AJPS2020821 article A Ajeet ajeet_pharma111@rediffmail.com 1 Babita Aggarwal 1 Santosh Kumar Verma 1 Ajeet Singh 2 Faculty of Pharmaceutical Sciences, Motherhood University, Roorkee, India Department of Pharmaceutical Sciences, J. S. University, Shikohabad, India 07 anti-HCV drugs have been processed and observed by docking analysis for understanding the binding patteren of drugs with COVID-19 main protease PDB ID: 6LU7 for any possibilities of protease inhibition. For docking analysis PyRx- Python Prescription 0.8 was used. This analysis reveals that the essential amino acids involved in binding of anti-HCV drugs to COVID-19 main protease PDB ID: 6LU7 are Threonine (THR), Cysteine (CYS), Histidine (HIS), Methionine (MET) and Proline (PRO). After docking analysis it was observed that Ledipasvir may be act as COVID-19 main protease inhibitor despite of being anti-HCV and may further be used in the treatment of COVID-19 infection after having proper clinical proofs. http://pubs.sciepub.com/ajps/8/2/1/ajps-8-2-1.pdf COVID-19 anti-HCV protease inhibition