eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2017-10-25 5 3 57 62 10.12691/ajps-5-3-1 AJPS2017531 article Seindé Espérance MEDOATINSA 1 2 Cokou Pascal AGBANGNAN DOSSA cokou2005@yahoo.fr 2 Sossa Pascal ATCHADE 3 Gbèdossou Sophie Reine BOGNINOU 3 Kossivi DOSSEH 4 Tchazou KPATCHA 4 Amegnona AGBONON 4 Hyacinthe AHISSOU 4 Dominique SOHOUNHLOUE 4 Laboratoire d’Etude et de Recherche en Chimie Appliquée (LERCA), Ecole Polytechnique d'Abomey-Calavi (EPAC), Université d'Abomey-Calavi (UAC), 01 BP 2009 Cotonou, Bénin Département de Génie de Biologie Humaine (GBH), Ecole Polytechnique d'Abomey-Calavi (EPAC), Université d'Abomey-Calavi (UAC), 01 BP 2009 Cotonou, Bénin Laboratoire de Physiologie et de Pharmacologie (LPP), Faculté des Sciences (FDS), Université de Lomé (UL), Togo The present study aims to evaluate "in vivo" the acute toxicity, antipyretic and antianemic activities of three plant recipes used in the treatment of malaria in southern Benin lake cities on Wistar rats. We note the presence of saponosides, phenolic compounds, sterols and terpenes in the recipes studied. The toxicity evaluation of the extracts revealed that they are practically non-toxic (LD50> 5g/kg body weight) according to the Hodge and Sterner classification. All the extracts investigated contain antipyretic molecules but only two extracts (aqueous extract obtain by decoction of the child's recipe: 36.07 ± 0.48°C, hydroethanolic macerated of the adult's recipe: 36.07 ± 0.33°C) showed significant antipyretic activity, similar to that of aspirin (36.03 ± 0.25°C) used as reference molecule in the present study. After evaluating the antianemic activity, we note that the extracts are not hemolytic. http://pubs.sciepub.com/ajps/5/3/1/ajps-5-3-1.pdf toxicity antipyretic antianemic metabolites plants malaria