@article{ajps2016421,
author={{Jain, Neetesh Kumar and Jain, Suman and Mehta, S C and Tonpay, S.D.},
title={Antiimplantation and Antiestrogenic Activity of <i>Boerhaavia Diffusa</i> Root Extract in Female Albino Rats},
journal={American Journal of Pharmacological Sciences},
volume={4},
number={2},
pages={15--19},
year={2016},
url={http://pubs.sciepub.com/ajps/4/2/1},
issn={2327-672X},
abstract={Disturbance of the natural steroid hormone balance can successfully disorganize the co-ordinate events involved in ovulation, ovum transport and implantation. Thus, compounds possessing estrogenic, progestation and anti-estrogenic, anti-progestational or anti-implantation activity may also exhibit anti-fertility activity. The present study was conducted to investigate the antiimplantation and antiestrogenic activity of <i>Boerhaavia diffusa</i> root extract in female rats. Female albino rats were taken and divided into three groups. Group I served as control, group II received methanolic extract at dose of 200 mg/kg body weight and group III received methanolic extract at dose of 400 mg/kg body weight. The root extract of <i>Boerhaavia diffusa</i> evaluated for anti-implantation activity, The methanolic extract at a dose of 200 mg/kg body weight inhibited pregnancy with mean number of implants 5.58 ¡À 0.34 [P&lt;0.001]. The same extract at a dose of 400mg/kg body weight significantly inhibited pregnancy with mean number of implants 4.47 ¡À 0.23 [P&lt;0.001]. The oral administration of the <i>Boerhaavia diffusa</i> methanolic root extract (BDME) at dose of 200 mg/kg and 400 mg/kg body weight caused a significant increase in the uterine weight in immature rats when compared to control, [P&lt;0.001]. These results indicate that the methanolic root extract of <i>Boerhaavia diffusa</i> contain bioactive compounds which may cause antiestrogenic activity. We can conclude that the methanolic extract of Boerhaavia diffusa root showed significant antifertility activity by means of potent antiestrogenic and anti-implantation, in a dose-dependent manner.},
doi={10.12691/ajps-4-2-1}
publisher={Science and Education Publishing}
}