@article{ajps2016411,
author={{Ajeet, A and Kumar, Pradeep and Gupta, Nishi},
title={<i>In-silico</i> Designing and Docking of Novel NĄŻ-(Substituted 2-Chlorophenyl)-2-(1, 3-benzodioxo-5-carbylidene) Hydrazine Carboamide as Anticonvulsant Agent},
journal={American Journal of Pharmacological Sciences},
volume={4},
number={1},
pages={1--6},
year={2016},
url={http://pubs.sciepub.com/ajps/4/1/1},
issn={2327-672X},
abstract={A series of NĄŻ-(Substituted 2-Chlorophenyl)-2-(1, 3-benzodioxo-5-carbylidene) Hydrazine carboamide were designed and carried with <i>in-silico </i>methods keeping in view the structural requirement of pharmacophore as potent anticonvulsant agents. These agents were then screened on the basis of docking procedures and further docking analysis of novel agents has been performed. The docking analysis reveals that compounds IPSR2, IPSR3, IPSR6 and IPSR9 perfectly docked with the T-type calcium channel with the highest bonding affinity range (-7 Kcal/mol to -7.5 Kcal/mol) and hydrogen bonds (5 to 7). Compounds IPSR4, IPSR5, IPSR7 and IPSR8 are found to dock with Na-channel with the bonding affinity range (-7.5 Kcal/mol to -8.3 Kcal/mol) and hydrogen bond (4 to 6). IPSR10 is found to dock with Glutamate receptor with significant bonding affinity and hydrogen bonds.},
doi={10.12691/ajps-4-1-1}
publisher={Science and Education Publishing}
}