Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 3 1 2015 02 27 Recent Advances in Development of Sulfonamide Derivatives and Their Pharmacological Effects- A Review 18 24 EN Ajeet Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, IFTM University, Moradabad Uttar Pradesh, India Arun K. Mishra Arvind Kumar AJPS2015314 10.12691/ajps-3-1-4 2015 01 29 2015 02 13 2015 02 27 First drugs which were largely used for chemotherapeutically and preventive use were the sulfonamides. Sulfonamides have a wide range of pharmacological activities such as against rheumatoid arthritis, anti-hypertensive, anti-epileptic, anti-bacterial, anti-protozoal, anti-fungal, non-peptidic vasopressin receptor antagonists, anti-inflammatory, and translation initiation inhibitors. These sulfonamides have a variety of synthetic reactions to work with. This review comprises of recent advances related to synthesis and pharmacological effects of sulfonamides especially in concern to anti-epileptic and anti-microbial agents.