eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2015-02-27 3 1 18 24 10.12691/ajps-3-1-4 AJPS2015314 article Recent Advances in Development of Sulfonamide Derivatives and Their Pharmacological Effects- A Review Ajeet ajeet_pharma111@rediffmail.com 1 Arun K. Mishra 1 Arvind Kumar 2 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, IFTM University, Moradabad Uttar Pradesh, India Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India First drugs which were largely used for chemotherapeutically and preventive use were the sulfonamides. Sulfonamides have a wide range of pharmacological activities such as against rheumatoid arthritis, anti-hypertensive, anti-epileptic, anti-bacterial, anti-protozoal, anti-fungal, non-peptidic vasopressin receptor antagonists, anti-inflammatory, and translation initiation inhibitors. These sulfonamides have a variety of synthetic reactions to work with. This review comprises of recent advances related to synthesis and pharmacological effects of sulfonamides especially in concern to anti-epileptic and anti-microbial agents. http://pubs.sciepub.com/ajps/3/1/4/ajps-3-1-4.pdf sulfonamide anti-epileptic anti-microbial