@article{ajps2015311,
author={{Ezeja, Maxwell I. and N.Omeh, Yusuf and Onoja, Samuel O. and Ukaonu, Ijeoma H.},
title={Anti-inflammatory and Antioxidant Activities of the Methanolic Leaf Extract of C<i>issus</i> <i>aralioides</i>},
journal={American Journal of Pharmacological Sciences},
volume={3},
number={1},
pages={1--6},
year={2015},
url={http://pubs.sciepub.com/ajps/3/1/1},
issn={2327-672X},
abstract={Inflammation and oxidative stress are features of many degenerative diseases. This study evaluated the anti-inflammatory and antioxidant activities of the methanolic leaf extract of <i>Cissus aralioides</i> <i>in vivo</i> and <i>in vitro</i>. The anti-inflammatory activity was evaluated using the carrageenan and formalin-induced paw edema models and Nitric oxide (NO) scavenging ability, while the antioxidant activity was evaluated using 1, 1-diphenyl-2-picryl hydrazyl (DPPH) photometric assay. In the anti-inflammatory study, doses of 150, 300 and 600 mg/kg of the extract were used orally. Acetylsalicylic acid (200 mg/kg) was used as a reference drug while concentrations of <i>Cissus aralioides</i> extract (CAE) ranging from 25- 800 ¦Ìg/ml were used for DPPH and NO scavenging ability. In the carrageenan-induced paw edema model, CAE caused dose-dependent increase in percentage edema inhibition, increasing percentage inhibition of edema from 0% in the negative control group to 41% at 6<SUP>th</SUP> h at 600 mg/kg. In the formalin-induced paw edema model, CAE significantly (p &lt; 0.05) and dose dependently increased the percentage edema inhibition and decreased the paw edema volumes on day 1. <i>Cissus aralioides</i> extract showed different percentage increase in the nitric oxide scavenging ability, increasing it from 24.94% at 25 ¦Ìg/ml to 57.41% at 800 ¦Ìg/ml while in the DPPH assay; CAE caused a concentration dependent increase in antioxidant activity from 1.88% at 25 ¦Ìg/ml to 52.55% at 400 ¦Ìg/ml. In conclusion, the results suggest that <i>Cissus aralioides</i><i> </i>may be of benefit in ameliorating inflammatory and oxidative stress conditions.},
doi={10.12691/ajps-3-1-1}
publisher={Science and Education Publishing}
}