eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2014-12-04 2 5B 8 11 10.12691/ajps-2-5B-3 AJPS201425B3 article Muhammad Azeem azeem.hamdard@gmail.com 1 2 Humaira Naureen 2 Madeeha Malik 2 Department of Pharmaceutics, Riphah Institute of Pharmaceutical Sciences, Islamabad, Pakistan Seven brands of ciprofloxacin (One multinational and six local) were evaluated in terms of their bioavailability and efficacy. Pharmaceutical Parameters like weight variation, hardness, disintegration, dissolution and content assay were determined. Antibacterial susceptibility assay was performed on standard Strain of Salmonella typhi (ATCC 14028). MIC and ZOI were assessed. The results of the study indicated that three local brands had content less than the stated claim of USP and one brand did not pass the disintegration and dissolution tests, so they cannot be used as therapeutic alternatives. Antibacterial assay showed less MIC value of the brands having greater drug content while drug with lesser amount had greater MIC value. Similarly, one local brand showed greater zone of inhibition (ZOI) as compared to multinational brand having more price than the local brand. http://pubs.sciepub.com/ajps/2/5B/3/ajps-2-5B-3.pdf minimum Inhibitory concentration (MIC) zone of inhibition (ZOI) United States Pharmacopoeia (USP) World Health Organization (WHO) Gastro-Intestinal Track (GIT) Muller Hinton Agar (MHA) Irrational Drug Use (IRDU)