Dear Label_Name,

Greetings! I hope you are well.

I am writing on behalf of an international publishing house, Science and Education Publishing, USA (http://www.sciepub.com).

Science and Education Publishing (SciEP) is a multidisciplinary open access publisher of Journals covering the fields of Science, Technology and Medicine. All SciEP publications are subject to high-quality peer review, editorial and production processes and are freely available online.

Welcome to the April, 2013 edition of SciEP newsletter, providing monthly summaries of articles on science & education related topics of interest to scientist and professionals. The mission of our journals is to provide an open access forum for publishing new findings on issues pertinent to scientific and academic field. We also invite you to submit original research papers, review articles, short reports, or case studies are considered for publication in our Multidisciplinary Journals.

American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

We have released issues of some journals on February 2013.
American Journal of Public Health Research
American Journal of Medical Sciences and Medicine
American Journal of Medical and Biological Research
American Journal of Pharmacological Sciences
American Journal of Clinical Medicine Research
American Journal of Nursing Research
American Journal of Cancer Prevention
American Journal of Medicine Studies
American Journal of Infectious Diseases and Microbiology
American Journal of Cardiovascular Disease Research
American Journal of Biomedical Research
American Journal of Mechanical Engineering
American Journal of Microbiological Research
Journal of Preventive Medicine
American Journal of Food and Nutrition
American Journal of Hypertension Research
American Journal of Sports Science and Medicine
Journal of Cancer Research and Treatment
American Journal of Zoological Research
Journal of Biomedical Engineering and Technology
American Journal of Microbiological Research
Biomedical Science and Engineering

We are pleased to announce that submissions are now being accepted for peer review for all the journals across all our subject areas in SciEP.

Please submit your manuscript via our online submission system:
http://www.sciepub.com/author/signin

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Kind regards,

David Rain
Email:join@sciepub.com
Science and Education Publishing (http://www.sciepub.com)

Breaking the Skin Barrier: Current Advancement in Drug Delivery via Skin

Yasser Shahzad*, Madeeha Malik*

North-West University, Centre of Excellence for Pharmaceutical Sciences, Potchefstroom, South AfricaHamdard University, Hamdard Institute of Pharmaceutical Sciences, Islamabad, Pakistan

Abstract:

Keywords:

Received August 15, 2014; Revised September 17, 2014; Accepted September 20, 2014

Citation: Yasser Shahzad, Madeeha Malik, Breaking the Skin Barrier: Current Advancement in Drug Delivery via Skin. American Journal of Pharmacological Sciences, 2 (5A). 0-0. January 2014. doi:10.12691/ajps-2-5A-0

Human skin provides a protective function by imposing physicochemical limitations to the type of permeant that can navigate the barrier. Transdermal drug delivery offers compelling opportunities to address the low bioavailability of many oral drugs; the pain and inconvenience associated with the injections; and the limited controlled release options of both. For novel delivery methods to succeed and compete with those already on the market, the prime issues that require consideration include device design and safety, efficacy, ease of handling, and cost-effectiveness. Beside this the major challenges and their solutions in designing optimum formulations for skin delivery along with in-depth mechanism relating to the strategies of overcoming the barrier properties of the skin needs to be further explored.

This short special issue of American Journal of Pharmacological Sciences brings together a couple of insightful papers that address some of these issues related to various strategies which have emerged in recent years, to optimise transdermal drug delivery system. The goal of this special issue is to advance the science and methodology in the field of drug delivery and to let the readers become more knowledgeable regarding recent advancements in optimising transdermal drug delivery designs. The first paper has highlighted the importance of ability to incorporate drugs into nanoparticles so as to achieve the ultimate goals of controlled release and site-specific drug delivery. The authors have emphasised on the need of investigating lipid nanoparticles which might offer possibilities to develop new therapeutic regimens in treatment of complex diseases. The second paper has evaluated the synergistic effect of penetration enhancers, namely propylene glycol (PG) and sodium lauryl Sulphate (SLS) on the transdermal absorption of 2-Methyl-2-phenoxy-propionic acid (MPA) with the aid of a statistical method, namely response surface methodology (RSM). The paper reported the combination of PG and SLS to be utilised successfully as permeation enhancers for transdermal drug delivery of MPA with minimal side effects.