eng Science and Education Publishing American Journal of Pharmacological Sciences 2014-02-08 2 1 27 31 10.12691/ajps-2-1-6 AJPS2014216 article Nagiat T Hwisa 1 Fathi H Assaleh 1 Sumalatha Gindi 2 Fauzi El Melad 2 Babu Rao Chandu drchandubaburao@gmail.com 2 3 Prakash Katakam 3 3 Faculty of Pharmacy, University of Zawia, Az Zawiyah, Libya Department of Pharmacology, Hindu College of Pharmacy, Guntur, India The objective was to investigate the antiurolithiatic activity of aqueous plant extract of Melia azadirachta using the zinc disc implantation model in male Wistar albino rats. A significant increase in urinary excretion of calcium, oxalate, magnesium and phosphate was observed after four weeks of implantation of zinc discs. After treatment with aqueous extract of Melia azadirachta caused a significant reduction (p < 0.001) in stone weight and urinary excretion of electrolytes in both the preventive and curative group of animals as compared to those of control groups. This explains the effect of the aqueous extract of Melia azadirachta in preventing urolithiasis (59%) and dissolving the pre-formed magnesium ammonium phosphate type of stones (46%). The possible mechanism could be due to the urinary stone-formation, lowering, antioxidant, diuretic, nephroprotective constituents present in Melia azadirachta. These results suggest the usefulness of aqueous plant extract of Melia azadirachta as an antiurolithiatic agent. http://pubs.sciepub.com/ajps/2/1/6/ajps-2-1-6.pdf Melia azadirachtaantiurolithiatic activityaqueous extractrats