@article{ajps2014216,
author={{Hwisa, Nagiat T and Assaleh, Fathi H and Gindi, Sumalatha and Melad, Fauzi El and Chandu, Babu Rao and Katakam, Prakash},
title={A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats},
journal={American Journal of Pharmacological Sciences},
volume={2},
number={1},
pages={27--31},
year={2014},
url={http://pubs.sciepub.com/ajps/2/1/6},
abstract={The objective was to investigate the antiurolithiatic activity of aqueous plant extract of <i>Melia azadirachta</i> using the zinc disc implantation model in male Wistar albino rats. A significant increase in urinary excretion of calcium, oxalate, magnesium and phosphate was observed after four weeks of implantation of zinc discs. After treatment with aqueous extract of <i>Melia azadirachta</i> caused a significant reduction (<i>p</i><i> </i>&lt; 0.001) in stone weight and urinary excretion of electrolytes in both the preventive and curative group of animals as compared to those of control groups. This explains the effect of the aqueous extract of <i>Melia azadirachta</i> in preventing urolithiasis (59%) and dissolving the pre-formed magnesium ammonium phosphate type of stones (46%). The possible mechanism could be due to the urinary stone-formation, lowering, antioxidant, diuretic, nephroprotective constituents present in <i>Melia azadirachta</i>. These results suggest the usefulness of aqueous plant extract of <i>Melia azadirachta</i> as an antiurolithiatic agent.},
doi={10.12691/ajps-2-1-6}
publisher={Science and Education Publishing}
}