eng Science and Education Publishing American Journal of Pharmacological Sciences 2014-02-07 2 1 24 26 10.12691/ajps-2-1-5 AJPS2014215 article Nwaehujor Chinaka O chinaka_n@yahoo.com 1 Asuzu Onyeka V 2 Asuzu Isaac U 3 Department of Biochemistry, Faculty of Basic Medical, Sciences, University of Calabar, P.M.B. 1115, Calabar, Nigeria Department of Animal Production and Health, Faculty of Agriculture, Federal University, Oye, Oye-ekiti, Ekiti State, Nigeria Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for membrane stabilizing potentials in red blood cells of alloxan-induced diabetic albino Swiss mice. Blood from diabetic animals treated with different doses of the compound (8, 4, 2 mg/kg) and Glibenclamide (2 mg/kg) were measured for membrane stability at different saline concentrations. The MCF values and their corresponding percentage stabilization were increased in the treatment groups compared to the negative control. The result suggests that D-3-O-methylchiroinositol possesses membrane stabilizing potentials. http://pubs.sciepub.com/ajps/2/1/5/ajps-2-1-5.pdf D-3-O-methylchiroinositolPiliostigma thonningiiosmotic fragilitymembrane stabilizationred blood cellsdiabetesalbino Swiss mice