@article{ajps2014211,
author={{Asif, Mohammad and Singh, Anita and Lakshmayya, L},
title={<i>In-vivo</i> Anticonvulsant and <i>In-vitro</i> Antimycobacterial Activities of 6-Aryl Pyridazine-3(<i>2H</i>)-One Derivatives},
journal={American Journal of Pharmacological Sciences},
volume={2},
number={1},
pages={1--6},
year={2014},
url={http://pubs.sciepub.com/ajps/2/1/1},
abstract={Some 6-aryl-4,5-dihydropyridazin-3(<i>2H</i>)-one compounds (<b>2a-f</b>) were synthesized and evaluated for their <i>in-vivo</i> anticonvulsant activities against maximal electro shock (MES) and isoniazid (INH) induced seizure methods at 50mg/kg dose level. Neurotoxicity of all compounds (<b>2a-f</b>) was also tested at 50, 100 and 200mg/kg dose level. The <i>in-vitro</i> antitubercular activity was evaluated against <i>Mycobacterium tuberculosis</i> H37Rv by using the Microplate Alamar Blue Assay (MABA) method. The result showed that all compounds (<b>2a-f</b>) showed significant anticonvulsant activity against both MES and INH induced convulsion methods. Among all compounds (<b>2a-f</b>), highest activity was exhibited by compound <b>2e </b>against MES and compound <b>2b </b>against<b> </b>INH-induced convulsion methods. In both methods, phenytion sodium (25mg/kg) and sodium valproate (50mg/kg) were used as reference drugs. All compounds did not showed any neurotoxicity up to 200mg/kg dose level. In antitubercular activity, minimum inhibitor concentration of compound <b>2e</b> and <b>2f</b> was 12.5¦Ìg/ml and other remaining compounds (<b>2a-d</b>) were showed 25¦Ìg/ml when compared with reference drugs Isoniazid (3.12¦Ìg/ml), Pyrizinamide (3.12¦Ìg/ml) and Streptomycin (6.25¦Ìg/ml).},
doi={10.12691/ajps-2-1-1}
publisher={Science and Education Publishing}
}