eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2023-06-09 11 1 21 27 10.12691/ajps-11-1-4 AJPS20231114 article Jyoti Singh 1 Amit Jaiswal ajaiswal8787@gmail.com 2 Anil Kumar Pal 2 Department of Chemistry, University of Allahabad, Prayagraj, 211002, India Department of Chemistry, C.M.P. Degree College, 211002, Prayagraj, India Tin has a variety of advantageous biological effects. The majority of tin complexes are effective against a wide range of different disorders, including convulsion, tumor, cancer, malaria, tuberculosis, and diabetes. The majority of the tin complex exhibits drug-like antibacterial and antifungal properties. Tin complexes have greater activity than free ligands like macrocyclic and Schiff bases. A new series of tin (II) and tin (IV) complexes were formed as a result of n - heterocyclic Schiff base ligand. Three tin (IV) complexes, H-ClQ=5, 7-dichloro-8-hydroxylquinoline, H-BrQ=5, 7-dibromo-8-hydroxylquinoline, and H-ClIQ=5-chloro-7-iodo-8-hydroxylquinoline, were created. There in vitro information about the condition against the cell lines BEL7404, SKOV-3, NCI-H460, and HL-770 Having IC50 values that range from 20 nm to 5.11 mM, the compound exhibits strong anti-proliferative action against the investigated cell lines. Most complexes showed significantly increased cytotoxicity as compared to 5, 7-dihalo-8-quinolinol (except 2 against SKOV-3 and NCI-H460). Additionally, they showed some selective cytotoxicity that favoured the tested tumor cells over the healthy HL-7702 cells from the human liver. Complexes 1-3 bind DNA more firmly compared to their quinolinol ligands. Macrocyclic molecules, which include porphyrin rings connected to metal ions in cytochromes, heamoglobin, and chlorophyll, may have significant effects on the biochemistry of biological systems. The biological applications of complexes of transition metals with ligands have been the subject of extensive research. The most likely binding mode for the aggregates with their quinolinol ligands is intercalation. The significance of tin applications in biological processes is explained in this review paper. http://pubs.sciepub.com/ajps/11/1/4/ajps-11-1-4.pdf tincomplexes biological activity macrocyclic ligands and schiff base ligands