@article{ajps20231112,
author={{Herman, Akassa and Lazare, Peneme Bonaventure Max and Arnauld, Etou Ossibi Wilfrid and Jonas, Morabandza Cyr and Roselyne, Kanga Marie and Aphrodite, Goma Dinouvanza L¨¨ges and Antoine, Abena Ange},
title={Androgenic and Antioxidant Effects of Ethanolic Extract of <i>Strychnos camptoneura</i> (longaniaceae) Trunk Bark in Male Wistar Rats},
journal={American Journal of Pharmacological Sciences},
volume={11},
number={1},
pages={8--14},
year={2023},
url={http://pubs.sciepub.com/ajps/11/1/2},
issn={2327-672X},
abstract={The main purpose of the present study was to evaluate the androgenic and antioxydant effects of ethanolic extract of <i>Strychnos</i> <i>camptoneura</i> trunk bark in Wistar rats. For this purpose, 20 rats were randomly arranged in 4 lots of 5 animals each and received respectively for lots 1 and 2 distilled water and testosterone enanthate and lots 3 and 4 treated with ethanolic extract of <i>Strychnos</i> <i>camptoneura</i> (100 and 250 mg /kg). It appears from this study that the administration of ethanolic extract of <i>Strychnos</i> <i>camptoneura</i> orally at the doses studied causes significant increases in body weight gain (p &lt; 0.05; p &lt; 0.01 and p &lt; 0.001) in rats in contrast to the animals of the negative control lot that received distilled water. Administration of <i>Strychnos</i> <i>camptoneura</i> extract at the doses studied did not induce any significant change (P > 0.05) in the relative weights of testes, vas deferens, seminal vesicles, and penis compared to negative control rats. Furthermore administration of ethanolic extract of <i>Strychnos</i> <i>camptoneura</i> at the doses studied induced a significant increase (p &lt; 0.01 and p &lt; 0.001) in serum and testicular testosterone levels in rats compared to those treated with distilled water. Chemical analyses performed in this study revealed the presence of total polyphenols (TPP) and flavonoids in the ethanolic extract of <i>Strychnos</i> <i>camptoneura</i>. These results suggest that the ethanolic extract of <i>Strychnos camptoneura</i> would have androgenic and antioxidant properties and would justify its use in traditional Congolese medicine for the treatment of male infertility.},
doi={10.12691/ajps-11-1-2}
publisher={Science and Education Publishing}
}