eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2023-01-12 11 1 1 7 10.12691/ajps-11-1-1 AJPS20231111 article Elion Itou RDG romaricelion@gmail.com 1 2 3 Etou Ossibi AW 3 3 Morabandza CJ 4 Boumba Y 4 Abena AA 4 Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Sciences and Techniques, Marien Ngouabi University, BP 69, Brazzaville-Congo Department of Natural Sciences, Ecole Normale Sup¨Śrieure, Marien Ngouabi University, B.P 69, Brazzaville - Congo Covid-Organics is an improved traditional medicine made from a plant called Artemisia annua Linn. It is developed by the Malagasy Institute for Applied Research with the aim is to treat coronavirus disease or Covid-19. The present study aims to justify the use of Covid-Organics by evaluating the anti-inflammatory, analgesic and antipyretic activities. Acute inflammation was induced by using the carrageenan and formaldehyde models. The results obtained show that Covid-Organics at the doses used significantly reduces (p<0.05; p<0.01; p<0.001) the edema induced by carrageenan and formaldehyde. Chronic inflammation was evalueted using the model of formaldehyde induced arthritis in rat. Results obtained show that Covid-Organics and diclofenac (standard drug) significantly reduce (p<0.001) the evolution of edema throughout the period of the experiment compared to the control group. The analgesic effect was evaluated by using the method of acetic acid and formaldehyde induced pain. Covid-Organics significantly reduced (p<0.001) the number of abdominal writhing induced by acetic acid, as well as the number of formaldehyde-induced paw licking and biting (p<0.01 and p<0.001). The antipyretic effect was induced using brewer's yeast induced pyrexia. The results obtained showed that Covid-Organics (0.6 and 1.2 mL/100g) increased significantly (p < 0.05; p < 0.01 and p < 0.001) pyrexia induced by brewer's yeast compared the control group. In conclusion, Covid-Organics (0.6 and 1.2 mL/100g) has anti-inflammatory, analgesic and antipyretic effects. These observations justify justify the use of Covid-Organics against the symptoms of coronavirus disease. http://pubs.sciepub.com/ajps/11/1/1/ajps-11-1-1.pdf anti-inflammatory analgesic antipyretic Covid-Organics