@article{ajps20231111,
author={{RDG, Elion Itou and AW, Etou Ossibi and CJ, Morabandza and Y, Boumba and AA, Abena},
title={Contribution to the Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of <i>Covid-Organics</i>},
journal={American Journal of Pharmacological Sciences},
volume={11},
number={1},
pages={1--7},
year={2023},
url={http://pubs.sciepub.com/ajps/11/1/1},
issn={2327-672X},
abstract={<i>Covid-Organics</i> is an improved traditional medicine made from a plant called <i>Artemisia annua</i> Linn. It is developed by the Malagasy Institute for Applied Research with the aim is to treat coronavirus disease or Covid-19. The present study aims to justify the use of <i>Covid-Organics</i> by evaluating the anti-inflammatory, analgesic and antipyretic activities. Acute inflammation was induced by using the carrageenan and formaldehyde models. The results obtained show that <i>Covid-Organics</i> at the doses used significantly reduces (p&lt;0.05; p&lt;0.01; p&lt;0.001) the edema induced by carrageenan and formaldehyde. Chronic inflammation was evalueted using the model of formaldehyde induced arthritis in rat. Results obtained show that <i>Covid-Organics</i> and diclofenac (standard drug) significantly reduce (p&lt;0.001) the evolution of edema throughout the period of the experiment compared to the control group. The analgesic effect was evaluated by using the method of acetic acid and formaldehyde induced pain. <i>Covid-Organics</i> significantly reduced (p&lt;0.001) the number of abdominal writhing induced by acetic acid, as well as the number of formaldehyde-induced paw licking and biting (p&lt;0.01 and p&lt;0.001). The antipyretic effect was induced using brewer's yeast induced pyrexia. The results obtained showed that <i>Covid-Organics</i> (0.6 and 1.2 mL/100g) increased significantly (p &lt; 0.05; p &lt; 0.01 and p &lt; 0.001) pyrexia induced by brewer's yeast compared the control group. In conclusion, Covid-Organics (0.6 and 1.2 mL/100g) has anti-inflammatory, analgesic and antipyretic effects. These observations justify justify the use of <i>Covid-Organics</i> against the symptoms of coronavirus disease.},
doi={10.12691/ajps-11-1-1}
publisher={Science and Education Publishing}
}