eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2022-11-30 10 1 47 52 10.12691/ajps-10-1-8 AJPS20221018 article Dabir¨¦ Anankp¨¨tinan Prosper prosper.dabire@yahoo.fr 1 2 Som¨¦ Andouormwine Abel 2 Sawadogo Stanislas 2 Bonkoungou Edouard Windpouir¨¦ 2 Ecole Normale Sup¨¦rieure, 01 BP 1757 Ouagadougou 01, Burkina Faso Stereospermum kunthianum is a plant used in traditional medicine of Burkina Faso. Ethnobotanical survey showed that this plant have many virtues but the toxicity and the effect of the leaves part on uterine contraction are not yet documented. To fill this gap, we investigated the toxicity effect on mice and the pharmacological effect of Stereospermum kunthianum on the contraction of rat isolated uterine horns. The acute and subacute toxicities were studied firstly. Secondary, the uterine segments were isolated and exposed to different concentrations of the aqueous extract of Stereospermum kunthianum leaves, oxytocin and KCl. The results showed that Stereospermum kunthianum aqueous extract decreased the amplitude and frequency of contractions. IC50 values were 1.46 and 2.03 respectively for amplitude and frequency. Our study revealed that the extract inhibited uterine contractions induced by oxytocin and potassium chloride (KCl). These data suggest that Stereospermum kunthianum active compound could be used for calming uterine contractions. The effect of Stereospermum kunthianum showed that it could be useful to fight against diseases that caused uterotonic actions. It may be useful to prevent preterm birth and pain caused by menstruation, as indicated by its traditional use. http://pubs.sciepub.com/ajps/10/1/8/ajps-10-1-8.pdf Stereospermum kunthianum toxicity relaxant effects uterine contractility rat