eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2022-11-25 10 1 38 46 10.12691/ajps-10-1-7 AJPS20221017 article Morabandza Cyr Jonas moressejonas@gmail.com 1 2 Moulari Brice 2 2 3 Gomb¨¦ Assoungou Hermann 3 3 Abena Ange Antoine 3 3 Laboratory of Microbiology, infectiology and Immunology, higher normal school, Marien Ngouabi University B.P. 69, Brazzaville (Congo) Strychnos camptoneura is an essential ethnomedicinal plant of the Congolese traditional medicine known to prevent, mitigate or treat the skin diseases. We aimed to investigate the in vitro anti-inflammatory effects of the S. camptoneura seeds ethanolic extract (EE), using the human keratinocytes and dermal fibroblast cells, and the in vivo immuno-modulatory effects. The in vitro anti-inflammatory activity was evaluated using the lipopolysaccharide-induced inflammation model. For the in vivo immuno-modulatory activities of ethanolic extract, immune cells were quantified by flow cytometer technique. The results showed that EE exhibited a higher anti-inflammatory activity compared to a non-treated group. The immuno-modulatory assay revealed that EE stimulate the immune cells (CD3, NK cells) and circulating anti-inflammatory cytokines (IL-10 and IL-4). These results could constitute a scientific basis for using S. camptoneura in traditional medicine. http://pubs.sciepub.com/ajps/10/1/7/ajps-10-1-7.pdf Strychnos camptoneura cytotoxicity anti-inflammatory immuno-modulatory human cells immune cells