@article{ajps20221017,
author={{Jonas, Morabandza Cyr and Brice, Moulari and Hermann, Gomb¨¦ Assoungou and Antoine, Abena Ange},
title={<i>In vitro</i> Anti-inflammatory and <i>in vivo</i><i> </i>Immuno-modulatory Activities of Ethanolic Extract of <i>Strychnos camptoneura (Loganiaceae)</i><i> </i>Seeds},
journal={American Journal of Pharmacological Sciences},
volume={10},
number={1},
pages={38--46},
year={2022},
url={http://pubs.sciepub.com/ajps/10/1/7},
issn={2327-672X},
abstract={<i>Strychnos camptoneura</i> is an essential ethnomedicinal plant of the Congolese traditional medicine known to prevent, mitigate or treat the skin diseases. We aimed to investigate the <i>in vitro</i> anti-inflammatory effects of the <i>S. camptoneura</i> seeds ethanolic extract (EE), using the human keratinocytes and dermal fibroblast cells, and the <i>in vivo</i> immuno-modulatory effects. The <i>in vitro</i> anti-inflammatory activity was evaluated using the lipopolysaccharide-induced inflammation model. For the <i>in vivo</i> immuno-modulatory activities of ethanolic extract, immune cells were quantified by flow cytometer technique. The results showed that EE exhibited a higher anti-inflammatory activity compared to a non-treated group. The immuno-modulatory assay revealed that EE stimulate the immune cells (CD3, NK cells) and circulating anti-inflammatory cytokines (IL-10 and IL-4). These results could constitute a scientific basis for using <i>S. camptoneura</i> in traditional medicine.},
doi={10.12691/ajps-10-1-7}
publisher={Science and Education Publishing}
}