@article{ajps20221016,
author={{Al-Fakih, Abdulkawi Ali and Saif, Mohammed Mansour Saleh and Farhan, Mohammed Ameen and Al-Najjar, Dammag Rafik and Alhothifi, Mohammed Hamoud},
title={<i>In vitro</i> Antifungal Activities of Some Plant Extracts against Fungal Pathogens Causing Cutaneous Mycoses},
journal={American Journal of Pharmacological Sciences},
volume={10},
number={1},
pages={31--37},
year={2022},
url={http://pubs.sciepub.com/ajps/10/1/6},
issn={2327-672X},
abstract={Fungal infections are increasingly recognized as an emerging threat to public health. They are treated by antifungal drugs; however fungal resistance continues to increase and complicate patient management, despite the introduction of new antifungal drugs. Antifungal activities of crude extracts of seven plant species were evaluated against ten species of fungi causing cutaneous mycoses. The antifungal susceptibility testing of five commercial antifungal drugs against the tested fungi were also investigated. The plant extract showing the strongest activity was submitted to two-fold dilution broth method to determine the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC). All tested fungal species, except <i>C. albicans</i>, were susceptible to nystatin with inhibition zone diameters in the range of 20?28 mm. All fungal species were found to be resistant for fluconazole. The aqueous extract<i> </i>of <i>A. nilotica</i> showed a greater antifungal activity against all tested fungi, with inhibition zone diameters in the range of 13?24 mm. The lowest MIC value of <i>A. nilotica</i> was 0.62 mg/ml against all tested fungi, except <i>M. canis</i>,<i> E. floccosum</i>, and <i>C. albicans</i>, which showed MIC values of 1.25 mg/ml. Three plant species, namely <i>Cissus rotundifolia</i>, <i>Psiadia arabica</i>, and <i>Pulicaria jaubertii</i> were inactive against all tested fungi. In conclusion, <i>A</i>. <i>nilotica</i> had the most potent antifungal activity against the tested fungi. Therefore, <i>A</i>. <i>nilotica</i> might be potentially valuable as a source of natural antifungal agents.},
doi={10.12691/ajps-10-1-6}
publisher={Science and Education Publishing}
}