eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2022-10-22 10 1 26 30 10.12691/ajps-10-1-5 AJPS20221015 article Bassoueka DĄŻAvila Judica?l basdavila@gmail.com 1 Peneme Bonaventure Max Lazare 1 Abena Ange Antoine 2 Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Techniques, Marien Ngouabi University, BP. 69 Brazzaville, Congo Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, BP: 69 Brazzaville, Congo The present study aimed to evaluate the anticonvulsant and sedative effects of the aqueous extract of Crossopteryx febrifuga. Two pharmacological tests such induction of convulsions by Picrotoxin and Strychnine were carried out to evaluate the anticonvulsant effect of C. febrifuga roots. The two other tests performed for the sedative effect involved the motor activity test and the barbiturate sleep potentiation test in mice. The aqueous extract of Crossopteryx febrifuga roots at a dose of 200 mg/kg showed a significant increase (**p < 0.01 and *p < 0.05) in the time to onset of seizures induced by Picrotoxin and a non-significant increase in the time to onset of strychnine-induced seizures in mice. The extract caused a non-significant decrease in the duration of convulsions in mice at doses of 100 and 200 mg/kg. Crossopteryx febrifuga extract had no effect on motor activity. However, at a dose of 200 mg/kg the extract caused a significant increase (**p < 0.01 and *** p < 0.001) in the time to onset of sleep. http://pubs.sciepub.com/ajps/10/1/5/ajps-10-1-5.pdf anticonvulsant motor activity Crossopteryx febrifuga mice Picrotoxin