@article{ajps20221015,
author={{Judica?l, Bassoueka DĄŻAvila and Lazare, Peneme Bonaventure Max and Antoine, Abena Ange},
title={Evaluation of the Anticonvulsive Effects of the Aqueous Extract of the Roots of <i>Crossopteryx febrifuga</i> in Mice},
journal={American Journal of Pharmacological Sciences},
volume={10},
number={1},
pages={26--30},
year={2022},
url={http://pubs.sciepub.com/ajps/10/1/5},
issn={2327-672X},
abstract={The present study aimed to evaluate the anticonvulsant and sedative effects of the aqueous extract of <i>Crossopteryx febrifuga</i>. Two pharmacological tests such induction of convulsions by Picrotoxin and Strychnine were carried out to evaluate the anticonvulsant effect of <i>C. febrifuga</i> roots. The two other tests performed for the sedative effect involved the motor activity test and the barbiturate sleep potentiation test in mice. The aqueous extract of <i>Crossopteryx febrifuga</i> roots at a dose of 200 mg/kg showed a significant increase (**p &lt; 0.01 and *p &lt; 0.05) in the time to onset of seizures induced by Picrotoxin and a non-significant increase in the time to onset of strychnine-induced seizures in mice. The extract caused a non-significant decrease in the duration of convulsions in mice at doses of 100 and 200 mg/kg. <i>Crossopteryx febrifuga</i> extract had no effect on motor activity. However, at a dose of 200 mg/kg the extract caused a significant increase (**p &lt; 0.01 and *** p &lt; 0.001) in the time to onset of sleep.},
doi={10.12691/ajps-10-1-5}
publisher={Science and Education Publishing}
}